The methods you are mentioning require surgery or are uncomfortable. While I agree that the multidrug approach that OREX is using is less effective than the approach of the single drug by VVUS. I still think there is upside to OREX. I own a small quantity of OREX and will add to my position on pullbacks. I think that VVUS is the better company. Their last results indicated an average weight loss of 14.7 percent. I have a much larger position in VVUS.