There are five proteins that are involved. The circulate in the blood at different levels depending upon the stage of infection. Some appear early when the infection first occurs, then the proteins change as the infection reaches its highest intensity, then the proteins change when therapy becomes effective and finally the proteins change back when the infection is cured. It is only during the last two stages that antibody occurs. But you have to know what proteins to look for in the blood and form antibodies to those markers. Like PSA levels circulating in the blood of men with early stage prostate disease. If your antigen level is less than 1.0, you are good to go for a year. 1.0-2.0 the doctor will want to monitor you. above 2.0 the doctor will want to monitor you at 3 month intervals and above 4.0 or rising from 2.0 to 4.0 suddenly, that will get you biopsied. If you are a guy, of course.

But that is where the molecular scientists are looking. Pre-active immune response in the patient.

But this new type of revolutionary test requires a novel source of the antigens to be developed.